The significance of the enterohepatic circulation on the metabolism of digoxin in patients with the ability of intestinal conversion of the drug.


A cardiac patient had to be given a very high dosage of digoxin to attain therapeutic plasma level. The increased dosage requirement could partly be explained by reduced bioavailability due to intestinal conversion of digoxin. Consequently, the kinetics of the drug was examined before and after erythromycin treatment. Before treatment the determination of… (More)