The significance of the anti-class I antibody response. I. Clinical and pathologic features of anti-class I-mediated rejection.

@article{Halloran1990TheSO,
  title={The significance of the anti-class I antibody response. I. Clinical and pathologic features of anti-class I-mediated rejection.},
  author={Philip F. Halloran and Arturo Wadgymar and Stephen R Ritchie and Judy A. Falk and Kim Solez and Nagaraja Srinivasa},
  journal={Transplantation},
  year={1990},
  volume={49 1},
  pages={85-91}
}
In renal transplantation, preformed cytotoxic antibody against donor HLA class I antigens causes hyperacute rejection of renal allografts, but its pathogenic significance when it develops in the posttransplant period is unknown. In the present studies we describe the clinical and pathologic features of patients with rejection associated with anti-class I. In the course of 400 consecutive cadaveric renal transplants, 7 patients were identified who had antibody against donor class I HLA antigens… CONTINUE READING

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