The significance of substance P in physiological and malignant haematopoiesis.

@article{Nowicki2007TheSO,
  title={The significance of substance P in physiological and malignant haematopoiesis.},
  author={Michał Nowicki and Danuta Ostalska-Nowicka and Beata Kondraciuk and Bogdan Miśkowiak},
  journal={Journal of clinical pathology},
  year={2007},
  volume={60 7},
  pages={749-55}
}
The role of substance P (SP) in physiological haematopoiesis is well established. However, it also seems to be important in the neoplastic transformation of bone marrow, leading to the development of acute leukaemia in children, and also metastases to bone marrow of solid tumours (particularly neuroblastoma and breast cancer) in early stages of these diseases. This review summarises the available data on SP involvement in both processes. In the future, SP antagonists may be used as anti… CONTINUE READING
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