The significance of subclinical rejection and the value of protocol biopsies.

@article{Nankivell2006TheSO,
  title={The significance of subclinical rejection and the value of protocol biopsies.},
  author={Brian John Nankivell and Jeremy Robert Chapman},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2006},
  volume={6 9},
  pages={2006-12}
}
Subclinical rejection (SCR) is diagnosed by protocol histology with a maximal prevalence occurring early after transplantation, falling to low levels by 1 year. Needle-core biopsy is safe, and the histology obtained fairly reflects subclinical immune activity. Several studies have consistently shown that SCR is associated with chronic tubulointerstitial damage, subsequent renal dysfunction and reduced graft survival. SCR is effectively treated by pulse corticosteroid therapy, although increased… CONTINUE READING

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