The significance of pharmacodynamic measurements in the assessment of bioavailability and bioequivalence of psychotropic drugs using CEEG and dynamic brain mapping.

@article{Itil1986TheSO,
  title={The significance of pharmacodynamic measurements in the assessment of bioavailability and bioequivalence of psychotropic drugs using CEEG and dynamic brain mapping.},
  author={Turan M. Itil and Kurt Z. Itil},
  journal={The Journal of clinical psychiatry},
  year={1986},
  volume={47 Suppl},
  pages={20-7}
}
There are a variety of problems in evaluating the bioavailability of psychotropic drugs. Psychotropics have many metabolites; there are discrepancies between peripheral plasma levels and therapeutic effects, and psychotropics must penetrate the blood-brain barrier to have an effect on their target organ. Therefore, "classical" pharmacokinetic evaluation may… CONTINUE READING