The significance of non-human primates as preclinical models of human arthritic disease.

Abstract

BACKGROUND The broad immunological gap between inbred SPF-raised strains of mice and rats and the diverse rheumatoid arthritis (RA) patient population limits the predictive value of the existing disease models for clinical success of new therapies, in particular for those using highly specific biologicals. OBJECTIVE This review argues that because of… (More)
DOI: 10.1517/17460441.3.3.299

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@article{Vierboom2008TheSO, title={The significance of non-human primates as preclinical models of human arthritic disease.}, author={Michel P M Vierboom and E. C. Breedveld and Ivanela I. Kondova and Bert A 't Hart}, journal={Expert opinion on drug discovery}, year={2008}, volume={3 3}, pages={299-310} }