The significance of nitric oxide production in the brain after injury.

@article{Khaldi2002TheSO,
  title={The significance of nitric oxide production in the brain after injury.},
  author={Ahmad Khaldi and Chuang Chin Chiueh and Malcolm Ross Bullock and John J Woodward},
  journal={Annals of the New York Academy of Sciences},
  year={2002},
  volume={962},
  pages={53-9}
}
Glutamate toxicity has been implicated in many aspects of brain injury including traumatic, ischemic, and hemorrhagic damage. We have used in vitro as well as in vivo methods to measure NO production and to examine the role of NO in glutamate toxicity. In building our recombinant system, we used human kidney embryonic cells, HEK 293, as host for transfection of nNOS and NMDA receptor proteins. Cells cotransfected with NMDA and nNOS were more resistant to glutamate toxicity. This resistance… CONTINUE READING
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