The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory

@article{Akbar1993TheSO,
  title={The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory},
  author={A N Akbar and Nicola J. Borthwick and Mike Salmon and Wendy M. Gombert and Margarita Bofill and N M Shamsadeen and Darrell Pilling and Stuart Pett and Jane E. Grundy and George Janossy},
  journal={The Journal of Experimental Medicine},
  year={1993},
  volume={178},
  pages={427 - 438}
}
The bcl-2 gene product has been shown to prevent apoptotic cell death. We have now investigated the bcl-2 protein expression by resting and activated mature T cell populations. Freshly isolated CD45RO+ T cells within CD4+ and CD8+ subsets expressed significantly less bcl-2 than CD45RO- (CD45RA+) T cells (p < 0.001). When CD45RA+ T cells within both CD4+ and… CONTINUE READING