The significance of astroglial hypertrophy in Scrapie, Kuru, Multiple Sclerosis and old age together with a note on the possible nature of the scrapie agent

@article{Field2004TheSO,
  title={The significance of astroglial hypertrophy in Scrapie, Kuru, Multiple Sclerosis and old age together with a note on the possible nature of the scrapie agent},
  author={Ephraim Joshua Field},
  journal={Deutsche Zeitschrift f{\"u}r Nervenheilkunde},
  year={2004},
  volume={192},
  pages={265-274}
}
  • E. J. Field
  • Published 1 September 1967
  • Biology
  • Deutsche Zeitschrift für Nervenheilkunde
ZusammenfassungAuf gewisse pathomorphologische Ähnlichkeiten zwischen Scrapie, Kuru, Multiple Sklerose und Altersdegeneration wird hingewiesen. Ein gemeinsamer Faktor in diesen Veränderungen wird vermutet, bei dem es sich um hypertrophische Vorgänge in Gliazellen, ähnlich einer gutartigen Neoplasie, handelt. Diese Veränderungen könnten mit einer Aggregation von Polysaccharidketten im Cytoplasma in Beziehung stehen. Derartige Polysaccharidaggregate könnten als Foci einer weiteren Aggregation… 
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Scrapie: a review of its relation to human disease and ageing.
  • E. J. Field
  • Biology, Medicine
    Journal of medical genetics
  • 1976
TLDR
Modern interest in scrapie has been intensified since 1954, when Sigurdsson delivered three lectures in the University of London in which he drew attention to certain naturally occurring diseases of sheep in Iceland which could, however, be passaged experimentally.
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Data on astrocytic reaction, including naturally occurring or experimentally induced TSEs, is summarized and an interesting interaction between astroCytes and oligodendrocytes is discussed in detail.
Role of lipid in forming an infectious prion?
TLDR
The literature regarding the chemical nature of the infectious agent and the potential contribution from lipid molecules to prion infectivity is reviewed, and the important remaining questions in this research area are discussed.
THE PATHOGENESIS AND PATHOLOGY OF SCRAPIE
Although scrapie represents a major source of loss to the sheep industry, it has become increasingly apparent that its study can provide insight into an important group of enigmatic human
The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo
TLDR
The results show that while molecular dynamics may capture the features affecting dimerization in vitro, G127V inhibiting dimer formation of PrP, these are not evidenced in a more complex cellular system.
Creutzfeldt-Jakob disease: Clinical, EEG and neuropathological findings in a cluster of eleven patients
TLDR
While the clinical and EEG findings were uniform, the neuropathological changes were not: astrogliosis was always diffuse and widespread but the other typical changes (neuronal loss and spongiosis) varied greatly both in degree and location.
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TLDR
Electron microscopic examination of mouse scrapie brain has shown small vesicles in nerve cells to be formed by dilatation of endoplasmic reticulum sacs, suggesting that astroglial hypertrophy may interfere with nerve cell nutrition so that nervous disturbance results from neuroglial dysfunction.
FURTHER OBSERVATIONS ON THE PATHOLOGY OF KURU (A STUDY OF THE TWO CEREDKA IN SERIAL SECTION)
TLDR
The present study can corroborate most of the previous histopathological findings and report several features not previously emphasized, such as the very wide distribution of the typical plaques observed in the white matter, as well as in the cerebral and cerebellar cortex and basal ganglia, and note for the first time excessive vulnerability of the Iimbie and para-limbic system.
Nature of the Scrapie Virus
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It is suggested tentatively that the scrapie agent consists of a small nucleic acid core enclosed in a mucopolysaccharide or even polysaccharides coat, and further that the nucleic acids core is stabilized structurally by covalent bonds with the sugar residues in the coat.
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TLDR
Recent work has shown that there are specific degenerative changes in the brain in the hypothalamic-hypophyseal system and in the olivo-ponto-cerebellar system and that scrapie is not naturally infectious.
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The association between multiple sclerosis and rural or agricultural pursuits suggested by some early epidemiologists has not been borne out by most subsequent workers, and a reassessment of multiple sclerosis becomes important.
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An unusual rod-like structure enclosed within a vacuole is described as occurring in enlarged glial cells associated with the lesions encountered in an uncommonly acute case of multiple sclerosis
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TLDR
Arrays of longitudinally arranged tubular structures were found in the axoplasm of larger myelinated nerve fibres traversing the granular layer of the rat cerebellum and were especially frequent in rats suffering from scrapie.
Cytopathology of scrapie in the rat: an electron microscopie study of thalamic and hippocampal areas.
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