The signature sequence of voltage-gated potassium channels projects into the external vestibule.

@article{Aiyar1996TheSS,
  title={The signature sequence of voltage-gated potassium channels projects into the external vestibule.},
  author={Jayashree Aiyar and James P. Rizzi and G. A. Gutman and K. George Chandy},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 49},
  pages={31013-6}
}
A highly conserved motif, GYGD, contributes to the formation of the ion selectivity filter in voltage-gated K+ channels and is thought to interact with the scorpion toxin residue, Lys27. By probing the pore of the Kv1.3 channel with synthetic kaliotoxin-Lys27 mutants, each containing a non-natural lysine analog of a different length, and using mutant cycle analysis, we determined the spatial locations of Tyr400 and Asp402 in the GYGD motif, relative to His404 located at the base of the outer… CONTINUE READING

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