The signature of positive selection on standing genetic variation.

@article{Przeworski2005TheSO,
  title={The signature of positive selection on standing genetic variation.},
  author={Molly Przeworski and Graham M Coop and Jeffrey D. Wall},
  journal={Evolution; international journal of organic evolution},
  year={2005},
  volume={59 11},
  pages={2312-23}
}
Considerable interest is focused on the use of polymorphism data to identify regions of the genome that underlie recent adaptations. These searches are guided by a simple model of positive selection, in which a mutation is favored as soon as it arises. This assumption may not be realistic, as environmental changes and range expansions may lead previously neutral or deleterious alleles to become beneficial. We examine what effect this mode of selection has on patterns of variation at linked… CONTINUE READING
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