The signals for starvation response are transduced through elevated [Ca2+]i in Dictyostelium cells.

@article{Tanaka1998TheSF,
  title={The signals for starvation response are transduced through elevated [Ca2+]i in Dictyostelium cells.},
  author={Yuya Tanaka and Ryuji Itakura and Aiko Amagai and Yasuo Maeda},
  journal={Experimental cell research},
  year={1998},
  volume={240 2},
  pages={340-8}
}
The mechanism by which cells recognize starvation to allow subsequent cellular development was analyzed using Dictyostelium discoideum, with special emphasis on Ca2+ as a crucial signal transducer in intra- and intercellular communications. As was expected, the cytosolic Ca2+ concentration ([Ca2+]i) in aequorin-expressing cells (RHI76 derived from D. discoideum Ax-3) was temporarily increased, when 3-5 microM thapsigargin (Tg), a specific inhibitor of the Ca(2+)-ATPase, was added into the cells… CONTINUE READING