The signalling role of action potential depolarization in insulin secretion: metabolism-dependent dissociation between action potential increase and secretion increase by TEA.

@article{Willenborg2010TheSR,
  title={The signalling role of action potential depolarization in insulin secretion: metabolism-dependent dissociation between action potential increase and secretion increase by TEA.},
  author={Michael Willenborg and Hany Ghaly and Kathrin Hatlapatka and Kristyn Urban and Uwe Panten and Ingo Rustenbeck},
  journal={Biochemical pharmacology},
  year={2010},
  volume={80 1},
  pages={104-12}
}
The K(+) channel blocker, TEA is known to increase action potential amplitude and insulin secretion of mouse beta-cells when added to a nutrient secretagogue. In the presence of a maximally effective sulfonylurea concentration (2.7 microM glipizide) the nutrient secretagogue alpha-ketoisocaproic acid (KIC, 10mM) strongly increased insulin secretion (about elevenfold). Instead of enhancing the effect of KIC, TEA reduced the KIC-induced secretion by more than 50%. Also, the secretion rate… CONTINUE READING