The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest

  title={The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest},
  author={A. Graham and P. Francis-West and P. Brickell and A. Lumsden},
  • A. Graham, P. Francis-West, +1 author A. Lumsden
  • Published 1994
  • Biology, Medicine
  • Nature
  • THE pattern of skeletal structures and muscles in the branchial region of the head is profoundly influenced by the neural crest1, whose cells arise at discrete segmental levels of the chick hindbrain: specifically, rhombomeres (r)l + 2, r4 and r6, whereas r3 and r5 are crest-depleted2. We have demonstrated that an interaction between even-numbered rhombomeres and r3/r5 effects this depletion of neural crest, resulting in the sculpting of discrete migratory streams of neural crest3. This… CONTINUE READING
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