The signaling mechanism of ROS in tumor progression

  title={The signaling mechanism of ROS in tumor progression},
  author={W S Wu},
  journal={Cancer and Metastasis Reviews},
Reactive oxygen species (ROS) are recently proposed to be involved in tumor metastasis which is a complicated processes including epithelial–mesenchymal transition (EMT), migration, invasion of the tumor cells and angiogenesis around the tumor lesion. ROS generation may be induced intracellularly, in either NADPH oxidase- or mitochondria-dependent manner, by growth factors and cytokines (such as TGFβ and HGF) and tumor promoters (such as TPA) capable of triggering cell adhesion, EMT and… CONTINUE READING
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