The signal transduction pathway for the dopamine D1 receptor in the guinea-pig cochlea.

@article{Niu2006TheST,
  title={The signal transduction pathway for the dopamine D1 receptor in the guinea-pig cochlea.},
  author={Xianzhi Niu and Barbara Canlon},
  journal={Neuroscience},
  year={2006},
  volume={137 3},
  pages={981-90}
}
Dopamine released from lateral efferent fibers modulates the activity of the auditory nerve, but the signaling mechanism by which this is mediated is not known. The present study investigated the signal transduction pathway for the dopamine D1 receptor in the guinea-pig cochlea. D1 receptor immunolabeling was localized to the spiral ganglia neurons and at the base of the inner hair cells. Western immunoblotting on whole cochlear preparations revealed positive bands for the D1 receptor and for… CONTINUE READING

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