The signal-to-noise ratio as a measure of HA oligomer concentration: a MALDI-TOF MS study.

@article{Busse2006TheSR,
  title={The signal-to-noise ratio as a measure of HA oligomer concentration: a MALDI-TOF MS study.},
  author={Katja Busse and Marco Averbeck and Ulf Anderegg and Klaus Arnold and Jan C. Simon and J{\"u}rgen Schiller},
  journal={Carbohydrate research},
  year={2006},
  volume={341 8},
  pages={1065-70}
}
MALDI-TOF MS (matrix-assisted laser desorption and ionization time-of-flight mass spectrometry) was used to determine ng amounts of defined hyaluronan (HA) oligomers obtained by enzymatic digestion of high molecular weight HA with testicular hyaluronate lyase. The signal-to-noise (S/N) ratio of the positive and negative ion spectra represents a reliable concentration measure: Amounts of HA down to about 40 fmol could be determined and there is a linear correlation between the S/N ratio and the… CONTINUE READING