The signal peptide of a recently integrated endogenous sheep betaretrovirus envelope plays a major role in eluding gag-mediated late restriction.

@article{Armezzani2011TheSP,
  title={The signal peptide of a recently integrated endogenous sheep betaretrovirus envelope plays a major role in eluding gag-mediated late restriction.},
  author={Alessia Armezzani and Fr{\'e}d{\'e}rick Arnaud and Marco Caporale and Giuliapia di Meo and Leopoldo Iannuzzi and Claudio Murgia and Massimo Palmarini},
  journal={Journal of virology},
  year={2011},
  volume={85 14},
  pages={7118-28}
}
The exogenous and pathogenic Jaagsiekte sheep retrovirus (JSRV) coexists with highly related and biologically active endogenous retroviruses (enJSRVs). The endogenous enJS56A1 locus possesses a defective Gag polyprotein which blocks the late replication steps of related exogenous and endogenous retroviruses by a mechanism known as JSRV late restriction (JLR). Conversely, enJSRV-26, which most likely integrated into the sheep genome less than 200 years ago, is able to escape JLR. In this study… CONTINUE READING

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