The signal attenuation rat model of obsessive–compulsive disorder: a review

@article{Joel2006TheSA,
  title={The signal attenuation rat model of obsessive–compulsive disorder: a review},
  author={Daphna Joel},
  journal={Psychopharmacology},
  year={2006},
  volume={186},
  pages={487-503}
}
During the last 30 years, there have been many attempts to develop animal models of obsessive–compulsive disorder (OCD), in the hope that they may provide a route for furthering our understanding and treatment of this disorder. The present paper reviews a recently developed rat model of OCD, namely, signal attenuation. Results of pharmacological and lesion studies are presented and evaluated with respect to the pharmacology and pathophysiology of OCD. It is argued that signal attenuation is a… CONTINUE READING