The sigma-1 receptor modulates NMDA receptor synaptic transmission and plasticity via SK channels in rat hippocampus.

Abstract

The sigma receptor (sigmaR), once considered a subtype of the opioid receptor, is now described as a distinct pharmacological entity. Modulation of N-methyl-D-aspartate receptor (NMDAR) functions by sigmaR-1 ligands is well documented; however, its mechanism is not fully understood. Using patch-clamp whole-cell recordings in CA1 pyramidal cells of rat… (More)

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@article{Martina2007TheSR, title={The sigma-1 receptor modulates NMDA receptor synaptic transmission and plasticity via SK channels in rat hippocampus.}, author={Marzia Martina and Marie-Eve B Turcotte and Samantha Halman and R. Thomas Bergeron}, journal={The Journal of physiology}, year={2007}, volume={578 Pt 1}, pages={143-57} }