The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke.

@article{Ruscher2011TheSR,
  title={The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke.},
  author={K. Ruscher and M. Shamloo and Mattias Rickhag and I. Ladunga and Liza Soriano and L. Gisselsson and H. Toresson and Lily Ruslim-Litrus and D. Oksenberg and R. Urfer and B. Johansson and K. Nikolich and T. Wieloch},
  journal={Brain : a journal of neurology},
  year={2011},
  volume={134 Pt 3},
  pages={
          732-46
        }
}
Stroke leads to brain damage with subsequent slow and incomplete recovery of lost brain functions. Enriched housing of stroke-injured rats provides multi-modal sensorimotor stimulation, which improves recovery, although the specific mechanisms involved have not been identified. In rats housed in an enriched environment for two weeks after permanent middle cerebral artery occlusion, we found increased sigma-1 receptor expression in peri-infarct areas. Treatment of rats subjected to permanent or… Expand
117 Citations
Inhibition of CXCL12 Signaling Attenuates the Postischemic Immune Response and Improves Functional Recovery after Stroke
  • K. Ruscher, Enida Kuric, +4 authors T. Wieloch
  • Biology, Medicine
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2013
  • 69
Sigma-1 receptor activation alleviates blood-brain barrier dysfunction in vascular dementia mice
  • 6
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 69 REFERENCES
Nogo Receptor Antagonism Promotes Stroke Recovery by Enhancing Axonal Plasticity
  • 316
  • PDF
Apolipoprotein D is Elevated in Oligodendrocytes in the Peri-Infarct Region after Experimental Stroke: Influence of Enriched Environment
  • 42
Cellular and molecular mechanisms underlying neurorehabilitation after stroke in aged subjects.
  • 30
Enriched Environment Reduces Apolipoprotein E (ApoE) in Reactive Astrocytes and Attenuates Inflammation of the Peri-Infarct Tissue after Experimental Stroke
  • 45
Rapid Morphologic Plasticity of Peri-Infarct Dendritic Spines After Focal Ischemic Stroke
  • 151
Sigma-1 Receptor Activation Prevents Intracellular Calcium Dysregulation in Cortical Neurons during in Vitro Ischemia
  • 103
  • PDF
Neuronal Plasticity and Dendritic Spines: Effect of Environmental Enrichment on Intact and Postischemic Rat Brain
  • B. Johansson, P. Belichenko
  • Biology, Medicine
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2002
  • 249
  • PDF
Functional and cellular effects of environmental enrichment after experimental brain infarcts.
  • B. Johansson
  • Biology, Medicine
  • Restorative neurology and neuroscience
  • 2004
  • 90
  • PDF
Inosine induces axonal rewiring and improves behavioral outcome after stroke
  • 240
  • PDF
...
1
2
3
4
5
...