The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke.

@article{Ruscher2011TheSR,
  title={The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke.},
  author={Karsten Ruscher and Mehrdad Shamloo and Mattias Rickhag and Istv{\'a}n Ladunga and Liza R Soriano and L Lennart Gisselsson and H{\aa}kan Toresson and Lily Ruslim-Litrus and Donna Oksenberg and Roman Urfer and Barbro Birgitta Johansson and Karoly Nikolich and Tadeusz Wieloch},
  journal={Brain : a journal of neurology},
  year={2011},
  volume={134 Pt 3},
  pages={732-46}
}
Stroke leads to brain damage with subsequent slow and incomplete recovery of lost brain functions. Enriched housing of stroke-injured rats provides multi-modal sensorimotor stimulation, which improves recovery, although the specific mechanisms involved have not been identified. In rats housed in an enriched environment for two weeks after permanent middle cerebral artery occlusion, we found increased sigma-1 receptor expression in peri-infarct areas. Treatment of rats subjected to permanent or… CONTINUE READING
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