The sigma-1 receptor chaperone as an inter-organelle signaling modulator.

@article{Su2010TheSR,
  title={The sigma-1 receptor chaperone as an inter-organelle signaling modulator.},
  author={T P Su and Teruo Hayashi and Tangui Maurice and Shilpa J Buch and Arnold E Ruoho},
  journal={Trends in pharmacological sciences},
  year={2010},
  volume={31 12},
  pages={
          557-66
        }
}
Inter-organelle signaling plays important roles in many physiological functions. Endoplasmic reticulum (ER)-mitochondrion signaling affects intramitochondrial calcium (Ca(2+)) homeostasis and cellular bioenergetics. ER-nucleus signaling attenuates ER stress. ER-plasma membrane signaling regulates cytosolic Ca(2+) homeostasis and ER-mitochondrion-plasma membrane signaling regulates hippocampal dendritic spine formation. Here, we propose that the sigma-1 receptor (Sig-1R), an ER chaperone protein… CONTINUE READING

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