The sigma-1 receptor: roles in neuronal plasticity and disease.

  title={The sigma-1 receptor: roles in neuronal plasticity and disease.},
  author={Sa{\"i}d Kourrich and T. -P. Su and Michiko Fujimoto and Antonello Bonci Bonci},
  journal={Trends in neurosciences},
  volume={35 12},
Sigma-1 receptors (Sig-1Rs) have been implicated in many neurological and psychiatric conditions. Sig-1Rs are intracellular chaperones that reside specifically at the endoplasmic reticulum (ER)-mitochondrion interface, referred to as the mitochondrion-associated ER membrane (MAM). Here, Sig-1Rs regulate ER-mitochondrion Ca(2+) signaling. In this review, we discuss the current understanding of Sig-1R functions. Based on this, we suggest that the key cellular mechanisms linking Sig-1Rs to… CONTINUE READING
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