The sialyl-glycolipid stage-specific embryonic antigen 4 marks a subpopulation of chemotherapy-resistant breast cancer cells with mesenchymal features

@inproceedings{Aloia2015TheSS,
  title={The sialyl-glycolipid stage-specific embryonic antigen 4 marks a subpopulation of chemotherapy-resistant breast cancer cells with mesenchymal features},
  author={Andrea Aloia and Evgeniya Petrova and Stefan Tomiuk and Ute Bissels and Olivier D{\'e}as and Massimo Saini and Franziska M Zickgraf and Steve J Wagner and Saskia Spaich and Marc Wolf S{\"u}tterlin and Andreas Schneeweiss and Manuel Reitberger and Silvia R{\"u}berg and Bernhard Gerstmayer and David J Agorku and Sebastian Kn{\"o}bel and Annalisa Terranegra and Monica Falleni and Laura Soldati and Martin R Sprick and Andreas Trumpp and Jean-Gabriel Judde and Andreas Bosio and Stefano Cairo and Olaf Hardt},
  booktitle={Breast Cancer Research},
  year={2015}
}
Chemotherapy resistance resulting in incomplete pathologic response is associated with high risk of metastasis and early relapse in breast cancer. The aim of this study was to identify and evaluate biomarkers of treatment-resistant tumor cells. We performed a cell surface marker screen in triple-negative breast cancer patient-derived xenograft models treated with standard care genotoxic chemotherapy. Global expression profiling was used to further characterize the identified treatment-resistant… CONTINUE READING