The sialic acids. VI. Purification and properties of sialidase from Clostridium perfringens.

  title={The sialic acids. VI. Purification and properties of sialidase from Clostridium perfringens.},
  author={James T. Cassidy and George W. Jourdian and Saul Roseman},
  journal={The Journal of biological chemistry},
  volume={240 9},
In 1947, McCrae (1) demonstrated that filtrates obtained from cultures of Clostridium perfringens contained an enzyme that destroyed erythrocyte receptor sites, thereby inhibiting hemagglutination of red cells by myxovirus. Subsequently, hydrolases that cleave glycosidically bound sialic acid, called neuraminidases or sialidases (2, 3), have been isolated from Vibrio cholerae (4)) myxoviruses (5-8)) Diplococcus pneumoniae (9, lo), Corynebacterium diphtheriae (II), and vertebrate tissues and… CONTINUE READING
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The chemistry and biology of sialic acids