The sialic acid component of the beta1 subunit modulates voltage-gated sodium channel function.

@article{Johnson2004TheSA,
  title={The sialic acid component of the beta1 subunit modulates voltage-gated sodium channel function.},
  author={Daniel V Johnson and Marty L Montpetit and Patrick J. Stocker and Eric S. Bennett},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 43},
  pages={
          44303-10
        }
}

• Daniel V Johnson, Marty L Montpetit, +1 author Eric S. Bennett
• Published in The Journal of biological chemistry 2004

Voltage-gated sodium channels (Nav) are responsible for initiation and propagation of nerve, skeletal muscle, and cardiac action potentials. Nav are composed of a pore-forming alpha subunit and often one to several modulating beta subunits. Previous work showed that terminal sialic acid residues attached to alpha subunits affect channel gating. Here we show that the fully sialylated beta1 subunit induces a uniform, hyperpolarizing shift in steady state and kinetic gating of the cardiac and two… CONTINUE READING

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