The shunt problem: control of functional shunting in normal and tumour vasculature

@article{Pries2010TheSP,
  title={The shunt problem: control of functional shunting in normal and tumour vasculature},
  author={Axel Radlach Pries and Michael H{\"o}pfner and Ferdinand A Le Noble and Mark W. Dewhirst and Timothy W. Secomb},
  journal={Nature Reviews Cancer},
  year={2010},
  volume={10},
  pages={587-593}
}
Networks of blood vessels in normal and tumour tissues have heterogeneous structures, with widely varying blood flow pathway lengths. To achieve efficient blood flow distribution, mechanisms for the structural adaptation of vessel diameters must be able to inhibit the formation of functional shunts (whereby short pathways become enlarged and flow bypasses long pathways). Such adaptation requires information about tissue metabolic status to be communicated upstream to feeding vessels, through… CONTINUE READING