The short-term effects of dl-propranolol on the wake-sleep cycle of the rat are related to selective changes in preoptic cyclic AMP concentration

@article{Zamboni1990TheSE,
  title={The short-term effects of dl-propranolol on the wake-sleep cycle of the rat are related to selective changes in preoptic cyclic AMP concentration},
  author={Giovanni Zamboni and Emanuele Perez and Roberto Amici and Prof P. L. Parmeggiani},
  journal={Experimental Brain Research},
  year={1990},
  volume={81},
  pages={107-112}
}
The short-term effects of the intraperitoneal administration of dl-propranolol on the wake-sleep cycle of the rat were studied in relation to the cyclic AMP concentration in the preoptic region and cerebral cortex. The results show that propranolol, but not saline, affected all stages of the wake-sleep cycle, increasing wakefulness, decreasing synchronized sleep and abolishing desynchronized sleep. These effects were associated with a decrement in cyclic AMP concentration both in wakefulness… CONTINUE READING

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