The short stature homeodomain protein SHOX induces cellular growth arrest and apoptosis and is expressed in human growth plate chondrocytes.

Abstract

Mutations in the homeobox gene SHOX cause growth retardation and the skeletal abnormalities associated with Léri-Weill, Langer, and Turner syndromes. Little is known about the mechanism underlying these SHOX-related inherited disorders of bone formation. Here we demonstrate that SHOX expression in osteogenic stable cell lines, primary oral fibroblasts, and… (More)

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@article{Marchini2004TheSS, title={The short stature homeodomain protein SHOX induces cellular growth arrest and apoptosis and is expressed in human growth plate chondrocytes.}, author={Antonio Marchini and Tiina Marttila and Anja Winter and Sandra Caldeira and Ilaria Malanchi and R{\"{u}diger J{\"{o}rg Blaschke and Beate H{\"a}cker and Ercole Rao and Marcel Karperien and Jan Maarten Wit and Wiltrud Richter and Massimo Tommasino and Gudrun A Rappold}, journal={The Journal of biological chemistry}, year={2004}, volume={279 35}, pages={37103-14} }