The short form of the prolactin (PRL) receptor silences PRL induction of the beta-casein gene promoter.

@article{Berlanga1997TheSF,
  title={The short form of the prolactin (PRL) receptor silences PRL induction of the beta-casein gene promoter.},
  author={J J Berlanga and Josefa Predestinaci{\'o}n Garc{\'i}a-Ru{\'i}z and Martine Perrot-Applanat and Paul A. T. Kelly and Marc Edery},
  journal={Molecular endocrinology},
  year={1997},
  volume={11 10},
  pages={1449-57}
}
The PRL receptor (PRLR) is a member of the cytokine receptor superfamily. Rats and mice express two forms of PRLR, short (SPRLR) and long (LPRLR), which differ in the length and sequence of their cytoplasmic domains. We have analyzed the ability of each form of rat PRLR to transduce lactogenic signals in a bovine mammary gland epithelial cell line. The rat PRLR forms were expressed and detected by RT-PCR, indirect immunofluorescence, and cell surface ligand binding. When the biological activity… CONTINUE READING

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