The short form of RON is expressed in acute myeloid leukemia and sensitizes leukemic cells to cMET inhibitors

@article{Fialin2013TheSF,
  title={The short form of RON is expressed in acute myeloid leukemia and sensitizes leukemic cells to cMET inhibitors},
  author={Camille Fialin and Cl{\'e}ment Larrue and François Vergez and Jean Emmanuel Sarry and Sarah Bertoli and V{\'e}ronique Mansat-De Mas and C Saura Demur and Eric C M Delabesse and Bernard Payrastre and St{\'e}phane Manenti and Serge Roche and Christian R{\'e}cher},
  journal={Leukemia},
  year={2013},
  volume={27},
  pages={325-335}
}
Several receptor tyrosine kinases (TKs) are involved in the pathogenesis of acute myeloid leukemia (AML). Here, we have assessed the expression of the Recepteur d’Origine Nantais (RON) in leukemic cell lines and samples from AML patients. In a series of 86 AML patients, we show that both the full length and/or the short form (sf) of RON are expressed in 51% and 43% of cases, respectively. Interestingly, sfRON is not expressed in normal CD34+ hematopoietic cells and induces part of its oncogenic… CONTINUE READING

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