The short N-terminal domains of STIM1 and STIM2 control the activation kinetics of Orai1 channels.


STIM1 and STIM2 are dynamic transmembrane endoplasmic reticulum Ca(2+) sensors, coupling directly to activate plasma membrane Orai Ca(2+) entry channels. Despite extensive sequence homology, the STIM proteins are functionally distinct. We reveal that the short variable N-terminal random coil sequences of STIM1 and STIM2 confer profoundly different… (More)
DOI: 10.1074/jbc.C109.010900


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