The sheep estrogen receptor: cloning and regulation of expression in the hypothalamo-pituitary axis.

@article{Madigou1996TheSE,
  title={The sheep estrogen receptor: cloning and regulation of expression in the hypothalamo-pituitary axis.},
  author={Thierry Madigou and Christophe Tiffoche and Gwendal Lazennec and Jean Pelletier and M. L. Thieulant},
  journal={Molecular and cellular endocrinology},
  year={1996},
  volume={121 2},
  pages={153-63}
}
We have prepared an ovine pituitary cDNA library, isolated a clone containing the full-coding sequence of estrogen receptor (ER) cDNA, and determined its primary structure. This cDNA encodes a protein of 596 amino acids which shows great homology to other mammalian ER sequences, the highest degree being 95% with the porcine receptor. Northern blot analysis of ovine pituitary RNA revealed a 6.3 kb transcript. This receptor was showed to bind a consensus ERE and to be transcriptionally activated… CONTINUE READING

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