The sheddase activity of ADAM17/TACE is regulated by the tetraspanin CD9

@article{GutirrezLpez2011TheSA,
  title={The sheddase activity of ADAM17/TACE is regulated by the tetraspanin CD9},
  author={M. Guti{\'e}rrez-L{\'o}pez and {\'A}lvaro Gilsanz and M. Y{\'a}{\~n}ez-M{\'o} and Susana Ovalle and E. Lafuente and C. Dom{\'i}nguez and Peter N. Monk and I. Gonz{\'a}lez-{\'A}lvaro and F. S{\'a}nchez-Madrid and C. Caba{\~n}as},
  journal={Cellular and Molecular Life Sciences},
  year={2011},
  volume={68},
  pages={3275-3292}
}
  • M. Gutiérrez-López, Álvaro Gilsanz, +7 authors C. Cabañas
  • Published 2011
  • Chemistry, Medicine
  • Cellular and Molecular Life Sciences
  • ADAM17/TACE is a metalloproteinase responsible for the shedding of the proinflammatory cytokine TNF-α and many other cell surface proteins involved in development, cell adhesion, migration, differentiation, and proliferation. Despite the important biological function of ADAM17, the mechanisms of regulation of its metalloproteinase activity remain largely unknown. We report here that the tetraspanin CD9 and ADAM17 partially co-localize on the surface of endothelial and monocytic cells. In situ… CONTINUE READING
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    References

    SHOWING 1-10 OF 58 REFERENCES
    Tetraspanins Regulate ADAM10-Mediated Cleavage of TNF-α and Epidermal Growth Factor1
    • 102
    • Highly Influential
    • PDF
    Tetraspanins regulate ADAM10-mediated cleavage of TNF-alpha and epidermal growth factor.
    • 59
    • Highly Influential
    The ADAM metalloproteinases
    • 897
    TACE/ADAM-17 enzymatic activity is increased in response to cellular stimulation.
    • 111
    Integrin α5β1 and ADAM-17 Interact in Vitro and Co-localize in Migrating HeLa Cells*
    • 58
    • PDF
    Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells.
    • 45
    The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions.
    • 351
    Functional Analysis of the Domain Structure of Tumor Necrosis Factor-α Converting Enzyme*
    • 375
    • PDF
    Evidence for Regulation of the Tumor Necrosis Factor α-Convertase (TACE) by Protein-tyrosine Phosphatase PTPH1*
    • 127
    • PDF