The sheddase activity of ADAM17/TACE is regulated by the tetraspanin CD9

  title={The sheddase activity of ADAM17/TACE is regulated by the tetraspanin CD9},
  author={M. Guti{\'e}rrez-L{\'o}pez and {\'A}lvaro Gilsanz and M. Y{\'a}{\~n}ez-M{\'o} and Susana Ovalle and E. Lafuente and C. Dom{\'i}nguez and Peter N. Monk and I. Gonz{\'a}lez-{\'A}lvaro and F. S{\'a}nchez-Madrid and C. Caba{\~n}as},
  journal={Cellular and Molecular Life Sciences},
  • M. Gutiérrez-López, Álvaro Gilsanz, +7 authors C. Cabañas
  • Published 2011
  • Chemistry, Medicine
  • Cellular and Molecular Life Sciences
  • ADAM17/TACE is a metalloproteinase responsible for the shedding of the proinflammatory cytokine TNF-α and many other cell surface proteins involved in development, cell adhesion, migration, differentiation, and proliferation. Despite the important biological function of ADAM17, the mechanisms of regulation of its metalloproteinase activity remain largely unknown. We report here that the tetraspanin CD9 and ADAM17 partially co-localize on the surface of endothelial and monocytic cells. In situ… CONTINUE READING
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