The shed ectodomain of type XIII collagen associates with the fibrillar fibronectin matrix and may interfere with its assembly in vitro.

@article{Visnen2006TheSE,
  title={The shed ectodomain of type XIII collagen associates with the fibrillar fibronectin matrix and may interfere with its assembly in vitro.},
  author={Marja-Riitta V{\"a}is{\"a}nen and Timo V{\"a}is{\"a}nen and Hongmin Tu and P{\"a}ivi L. Piril{\"a} and Raija T. Sormunen and Taina Pihlajaniemi},
  journal={The Biochemical journal},
  year={2006},
  volume={393 Pt 1},
  pages={43-50}
}
Type XIII collagen is a transmembrane collagen, which is known to exist also as a soluble variant due to ectodomain shedding. Earlier studies with the recombinant ectodomain have shown it to interact in vitro with a number of extracellular matrix proteins, e.g. Fn (fibronectin). In view of its strong binding to Fn, we examined in the present study whether the released soluble ectodomain can bind to the fibrillar Fn matrix under cell-culture conditions and, if so, influence its assembly. In this… CONTINUE READING