The sex steroid precursor DHEA accelerates cutaneous wound healing via the estrogen receptors.

@article{Mills2005TheSS,
  title={The sex steroid precursor DHEA accelerates cutaneous wound healing via the estrogen receptors.},
  author={Stuart J. Mills and Jason J. Ashworth and Stephen C. Gilliver and Matthew J. Hardman and Gillian S. Ashcroft},
  journal={The Journal of investigative dermatology},
  year={2005},
  volume={125 5},
  pages={1053-62}
}
Age-related impaired wound healing states lead to substantial morbidity and cost, with treatment in the USA resulting in an expenditure of over $9 billion per annum. Dehydroepiandrosterone (DHEA) is a ubiquitous adrenal hormone with immunomodulatory properties whose levels decline significantly with advanced age in humans. Conversion of DHEA locally to downstream steroid hormones leads to estrogenic and/or androgenic effects which may be important in age-related skin homeostasis, and which… CONTINUE READING
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