The sex steroid binding protein (SBP or SHBG) of human plasma: identification of Tyr-57 and Met-107 in the steroid binding site

@article{Ptra2000TheSS,
  title={The sex steroid binding protein (SBP or SHBG) of human plasma: identification of Tyr-57 and Met-107 in the steroid binding site},
  author={P. P{\'e}tra and K. T. Woodcock and W. R. Orr and D. Nguyen and L. Sui},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2000},
  volume={75},
  pages={139-145}
}
Tyrosine-57 (Y57) and methionine-107 (M107) have been identified in the binding site of the sex steroid binding protein (SBP) (or sex hormone binding globulin) of human plasma by replacing the two amino acids with a number of residues of varying structure. Replacement of Y57 with phenylalanine resulted in a fourfold increase in the K(d) of 5 alpha-dihydrotestosterone but left the K(d) of 17 beta-estradiol unchanged. Except in two cases, no further loss in binding took place when replacing Y57… Expand

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