The sex-specific associations of the aromatase gene with Alzheimer’s disease and its interaction with IL10 in the Epistasis Project

@article{Medway2014TheSA,
  title={The sex-specific associations of the aromatase gene with Alzheimer’s disease and its interaction with IL10 in the Epistasis Project},
  author={Christopher W Medway and Onofre Combarros and Mario Cortina-Borja and Helen T Butler and Carla A. Ibrahim-Verbaas and Ren{\'e}e F. A. G. de Bruijn and Peter J Koudstaal and Cornelia M. van Duijn and M. Arfan Ikram and Ignacio Mateo and P{\'a}scual Sanchez-Juan and Michael G. Lehmann and Reinhard Heun and Heike Koelsch and Panagiotis Deloukas and Naomi Hammond and E. Coto and V. Gonz{\'a}lez {\'A}lvarez and Patrick Gavin Kehoe and Rachel M Barber and G. K. Wilcock and Kristelle S. Brown and Olivia Belbin and Donald R. Warden and A. David Smith and Kevin A Morgan and Donald J. Lehmann},
  journal={European Journal of Human Genetics},
  year={2014},
  volume={22},
  pages={216-220}
}
Epistasis between interleukin-10 (IL10) and aromatase gene polymorphisms has previously been reported to modify the risk of Alzheimer’s disease (AD). However, although the main effects of aromatase variants suggest a sex-specific effect in AD, there has been insufficient power to detect sex-specific epistasis between these genes to date. Here we used the cohort of 1757 AD patients and 6294 controls in the Epistasis Project. We replicated the previously reported main effects of aromatase… CONTINUE READING