The sex-determining region of the human Y chromosome encodes a finger protein

@article{Page1987TheSR,
  title={The sex-determining region of the human Y chromosome encodes a finger protein},
  author={David C. Page and Rebecca Mosher and Elizabeth M. Simpson and Elizabeth M. C. Fisher and Laura Grace Brown},
  journal={Cell},
  year={1987},
  volume={51},
  pages={1091-1104}
}
The presence or absence of the Y chromosome determines whether a mammalian embryo develops as a male or female. In humans, genetic deletion analysis of "sex-reversed" individuals has identified a small portion of the Y chromosome necessary and sufficient to induce testicular differentiation of the bipotential gonad. We report the cloning of a 230-kilobase segment of the human Y chromosome that contains some or all of the testis-determining factor gene (TDF), the master sex-determining locus… CONTINUE READING

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