The sex-determining gene doublesex in the fly Megaselia scalaris: conserved structure and sex-specific splicing.

@article{Kuhn2000TheSG,
  title={The sex-determining gene doublesex in the fly Megaselia scalaris: conserved structure and sex-specific splicing.},
  author={S. Kuhn and V. Sievert and W. Traut},
  journal={Genome},
  year={2000},
  volume={43 6},
  pages={
          1011-20
        }
}
The well-known sex-determining cascade of Drosophila melanogaster serves as a paradigm for the pathway to sexual development in insects. But the primary sex-determining signal and the subsequent step, Sex-lethal (Sxl), have been shown not to be functionally conserved in non-Drosophila flies. We isolated doublesex (dsx), which is a downstream step in the cascade, from the phorid fly Megaselia scalaris, which is a distant relative of D. melanogaster. Conserved properties, e.g., sex-specific… Expand
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