The severe and moderate phenotypes of heritable Mac-1, LFA-1 deficiency: their quantitative definition and relation to leukocyte dysfunction and clinical features.

@article{Anderson1985TheSA,
  title={The severe and moderate phenotypes of heritable Mac-1, LFA-1 deficiency: their quantitative definition and relation to leukocyte dysfunction and clinical features.},
  author={Donald C. Anderson and F C Schmalsteig and Milton J. Finegold and Bonnie J Hughes and Robert Rothlein and Lauri J Miller and Steve Kohl and Michael F Tosi and R L Jacobs and Thomas C Waldrop},
  journal={The Journal of infectious diseases},
  year={1985},
  volume={152 4},
  pages={668-89}
}
An inherited syndrome characterized by recurrent or progressive necrotic soft-tissue infections, diminished pus formation, impaired wound healing, granulocytosis, and/or delayed umbilical cord severance was recognized in four male and four female patients. As shown with subunit-specific monoclonal antibodies in immunofluorescence flow cytometry and 125I immunoprecipitation techniques, in addition to a NaB3H4-galactose oxidase labeling assay, granulocytes, monocytes, or lymphocytes from these… CONTINUE READING

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