The seven-transmembrane receptor Smoothened cell-autonomously induces multiple ventral cell types

@article{Hynes2000TheSR,
  title={The seven-transmembrane receptor Smoothened cell-autonomously induces multiple ventral cell types},
  author={Mary Hynes and Weilan Ye and Kevin Boyang Wang and Donna Stone and Maximilien Murone and Frederic Sauvage and Arnon Rosenthal},
  journal={Nature Neuroscience},
  year={2000},
  volume={3},
  pages={41-46}
}
Sonic Hedgehog (Shh) is a secreted protein that controls cell fate and mitogenesis in the developing nervous system. Here we show that a constitutively active form of Smoothened (Smo-M2) mimics concentration-dependent actions of Shh in the developing neural tube, including activation of ventral marker genes (HNF3β, patched, Nkx2.2, netrin-1), suppression of dorsal markers (Pax-3, Gli-3, Ephrin A5) and induction of ventral neurons (dopaminergic, serotonergic) and ventrolateral motor neurons… CONTINUE READING