The serum response factor coactivator myocardin is required for vascular smooth muscle development.

@article{Li2003TheSR,
  title={The serum response factor coactivator myocardin is required for vascular smooth muscle development.},
  author={Shijie Li and Da-zhi Wang and Zhigao Wang and J. A. Richardson and Eric N Olson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 16},
  pages={9366-70}
}
Formation of the vascular system requires differentiation and patterning of endothelial and smooth muscle cells (SMCs). Although much attention has focused on development of the vascular endothelial network, the mechanisms that control vascular SMC development are largely unknown. Myocardin is a smooth and cardiac muscle-specific transcriptional coactivator of serum response factor, a ubiquitous transcription factor implicated in smooth muscle gene expression. When expressed ectopically in… CONTINUE READING

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