The serum protein alpha2-HS glycoprotein/fetuin inhibits apatite formation in vitro and in mineralizing calvaria cells. A possible role in mineralization and calcium homeostasis.

@article{Schinke1996TheSP,
  title={The serum protein alpha2-HS glycoprotein/fetuin inhibits apatite formation in vitro and in mineralizing calvaria cells. A possible role in mineralization and calcium homeostasis.},
  author={Thorsten Schinke and Christiane Amendt and Andreas Trindl and O P{\"o}schke and Werner M{\"u}ller-Esterl and Willi Jahnen-Dechent},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 34},
  pages={20789-96}
}
We present data suggesting a function of alpha2-HS glycoproteins/fetuins in serum and in mineralization, namely interference with calcium salt precipitation. Fetuins occur in high serum concentration during fetal life. They accumulate in bones and teeth as a major fraction of noncollagenous bone proteins. The expression pattern in fetal mice confirms that fetuin is predominantly made in the liver and is accumulated in the mineralized matrix of bones. We arrived at a hypothesis on the molecular… CONTINUE READING

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