The serotonin2C receptor agonist Ro-60-0175 attenuates effects of nicotine in the five-choice serial reaction time task and in drug discrimination

  title={The serotonin2C receptor agonist Ro-60-0175 attenuates effects of nicotine in the five-choice serial reaction time task and in drug discrimination},
  author={Davide Quarta and Christopher G. Naylor and Ian P. Stolerman},
RationaleThere is evidence that serotonin2C (5-HT2C) receptors can modulate some behavioural effects of nicotine, but the generality of this action is not known.ObjectiveTo analyse the influence of the 5-HT2C agonist Ro-60-0175 on responses to nicotine in the five-choice serial reaction time task (5-CSRTT) and on its discriminative stimulus effect; these procedures constitute models for attention-enhancing and subjective effects of nicotine, respectively.Materials and methodsIn the 5-CSRTT… 

The 5-HT2C Receptor Agonist Lorcaserin Reduces Nicotine Self-Administration, Discrimination, and Reinstatement: Relationship to Feeding Behavior and Impulse Control

Results indicate that lorcaserin, and likely other selective 5-HT2C receptor agonists, similarly affect both food- and nicotine-motivated behaviors, and Nicotine-induced impulsivity, and highlight a therapeutic potential for 5- HT2C agonists such as lorcasersin beyond obesity into addictive behaviors, such as nicotine dependence.

Serotonin antagonists in the five-choice serial reaction time task and their interactions with nicotine

Treatment with SB-242084 enhanced all speed-related indices of performance to above the levels seen under the influence of nicotine alone, thus suggesting that 5-HT2C antagonists might be useful to decrease reaction times if used as an add-on therapy to treat attentional decline.

Ketanserin, a 5-HT2 receptor antagonist, decreases nicotine self-administration in rats.

Serotonin and Reward-Related Behavior: Focus on 5-HT2C Receptors

The overall behavioral profile of 5-HT2C agonists indicates that this class of drug has the potential for use as medication to treat substance abuse and dependence and is in an advanced stage of clinical testing for obesity.

Lateral Habenula 5-HT2C Receptor Function Is Altered by Acute and Chronic Nicotine Exposures

It is shown that acute and chronic nicotine exposure differentially affect the central 5-HT2CR function mainly in the LHb and this may be relevant in nicotine addiction and its treatment.

Differential effects of serotonin (5‐HT)2 receptor‐targeting ligands on locomotor responses to nicotine‐repeated treatment

The data indicate that 5‐HT2A receptors (but not 5-HT2C receptors) play a permissive role in the sensitizing effects of nicotine, while stimulation of 5‐ HT2A receptor receptors enhances the development of nicotine sensitization and activation of5‐HT 2C receptors is essential for the expression of Nicotine sensitization.

The monoamine oxidase inhibitor phenelzine enhances the discriminative stimulus effect of nicotine in rats

It is indicated that concomitant inhibition of MAOA and MAOB can enhance the discriminative stimulus effect of nicotine in rats.

New Findings on the Sensitivity of Free-Operant Timing Behaviour to 5-Hydroxytryptamine Receptor Stimulation

The results suggest that mCPP’s effect on timing is mediated by an agonistic action at 5-HT1A and 4-HT2A, but not 5- HT1B, receptors, while Ro-600175 had no effect on T50.



Attenuation of nicotine’s discriminative stimulus effects in rats and its locomotor activity effects in mice by serotonergic 5-HT2A/2C receptor agonists

RationaleReports have indicated that administration of nicotine inhibits, while withdrawal of chronically administered nicotine augments effects of serotonergic 5HT2A/2C agonists.ObjectiveIt was our

Studies to investigate the role of 5-HT(2C) receptors on cocaine- and food-maintained behavior.

The present series of studies suggest that, in addition to reducing food intake, 5-HT(2C) receptor agonists reduce cocaine-reinforced behavior, which would be consistent with electrophysiological and biochemical evidence suggesting an important modulatory influence of 5- HT( 2C) receptors on mesolimbic dopamine function.

The 5-HT2A receptor antagonist M100,907 attenuates motor and 'impulsive-type' behaviours produced by NMDA receptor antagonism

The results suggest that 5-HT2A receptor antagonists may normalise certain 'impulsive' behaviours produced by NMDA receptor hypofunction, as well as attenuate the hyperlocomotion and stereotypy produced by dizocilpine.

Effects of dopamine receptor antagonists on nicotine-induced attentional enhancement

Neither the D1- nor the D2-type dopamine receptor antagonist affected nicotine-induced improvements in signal detection, at doses that reversed dependence-related behavioural effects of nicotine in previous studies, suggesting these effects may be pharmacologically dissociable.

Nicotine as a discriminative stimulus in rats depleted of norepinephrine or 5-hydroxytryptamine

The experimental evidence indicates that nicotine's CNS cueing effect is mediated by norepinephrine, and this is discussed in light of the Burn and Rand hypothesis.

Injection of the 5-HT2C Receptor Agonist Ro60-0175 into the Ventral Tegmental Area Reduces Cocaine-Induced Locomotor Activity and Cocaine Self-Administration

Previously, we have shown that systemic administration of the 5-HT2C receptor agonist Ro60-0175 reduces cocaine-induced locomotor activity and cocaine self-administration. Ro60-0175 also alters the

Discriminative stimulus properties of nicotine: Further evidence for mediation at a cholinergic receptor

The finding that there is some correlation between the behavioural effects of these compounds and their actions at the nicotine binding site may indicate that the nicotine cue is mediated throuth a cholinergic receptor.

5-HT2A and 5-HT2C receptor antagonists have opposing effects on a measure of impulsivity: interactions with global 5-HT depletion

Data support the view that serotonergic regulation of impulsive behaviour through different members of the 5-HT2 receptor family is functionally heterogeneous.

Dopaminergic and cholinergic involvement in the discriminative stimulus effects of nicotine and cocaine in rats

Substitution of nicotine for cocaine may depend more on nicotine-induced dopamine release than does the nicotine-trained discriminative stimulus; there may be differential dopaminergic involvement after acute and repeated treatment with nicotine or cocaine.