The serotonin2C receptor agonist Ro-60-0175 attenuates effects of nicotine in the five-choice serial reaction time task and in drug discrimination

@article{Quarta2007TheSR,
  title={The serotonin2C receptor agonist Ro-60-0175 attenuates effects of nicotine in the five-choice serial reaction time task and in drug discrimination},
  author={Davide Quarta and Christopher G. Naylor and Ian P. Stolerman},
  journal={Psychopharmacology},
  year={2007},
  volume={193},
  pages={391-402}
}
RationaleThere is evidence that serotonin2C (5-HT2C) receptors can modulate some behavioural effects of nicotine, but the generality of this action is not known.ObjectiveTo analyse the influence of the 5-HT2C agonist Ro-60-0175 on responses to nicotine in the five-choice serial reaction time task (5-CSRTT) and on its discriminative stimulus effect; these procedures constitute models for attention-enhancing and subjective effects of nicotine, respectively.Materials and methodsIn the 5-CSRTT… 

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References

SHOWING 1-10 OF 66 REFERENCES

Attenuation of nicotine’s discriminative stimulus effects in rats and its locomotor activity effects in mice by serotonergic 5-HT2A/2C receptor agonists

RationaleReports have indicated that administration of nicotine inhibits, while withdrawal of chronically administered nicotine augments effects of serotonergic 5HT2A/2C agonists.ObjectiveIt was our

Studies to investigate the role of 5-HT(2C) receptors on cocaine- and food-maintained behavior.

The present series of studies suggest that, in addition to reducing food intake, 5-HT(2C) receptor agonists reduce cocaine-reinforced behavior, which would be consistent with electrophysiological and biochemical evidence suggesting an important modulatory influence of 5- HT( 2C) receptors on mesolimbic dopamine function.

The 5-HT2A receptor antagonist M100,907 attenuates motor and 'impulsive-type' behaviours produced by NMDA receptor antagonism

The results suggest that 5-HT2A receptor antagonists may normalise certain 'impulsive' behaviours produced by NMDA receptor hypofunction, as well as attenuate the hyperlocomotion and stereotypy produced by dizocilpine.

Effects of dopamine receptor antagonists on nicotine-induced attentional enhancement

Neither the D1- nor the D2-type dopamine receptor antagonist affected nicotine-induced improvements in signal detection, at doses that reversed dependence-related behavioural effects of nicotine in previous studies, suggesting these effects may be pharmacologically dissociable.

Nicotine as a discriminative stimulus in rats depleted of norepinephrine or 5-hydroxytryptamine

The experimental evidence indicates that nicotine's CNS cueing effect is mediated by norepinephrine, and this is discussed in light of the Burn and Rand hypothesis.

Injection of the 5-HT2C Receptor Agonist Ro60-0175 into the Ventral Tegmental Area Reduces Cocaine-Induced Locomotor Activity and Cocaine Self-Administration

Previously, we have shown that systemic administration of the 5-HT2C receptor agonist Ro60-0175 reduces cocaine-induced locomotor activity and cocaine self-administration. Ro60-0175 also alters the

Discriminative stimulus properties of nicotine: Further evidence for mediation at a cholinergic receptor

The finding that there is some correlation between the behavioural effects of these compounds and their actions at the nicotine binding site may indicate that the nicotine cue is mediated throuth a cholinergic receptor.

5-HT2A and 5-HT2C receptor antagonists have opposing effects on a measure of impulsivity: interactions with global 5-HT depletion

Data support the view that serotonergic regulation of impulsive behaviour through different members of the 5-HT2 receptor family is functionally heterogeneous.

Dopaminergic and cholinergic involvement in the discriminative stimulus effects of nicotine and cocaine in rats

Substitution of nicotine for cocaine may depend more on nicotine-induced dopamine release than does the nicotine-trained discriminative stimulus; there may be differential dopaminergic involvement after acute and repeated treatment with nicotine or cocaine.
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