The serotonin theory of depression: a systematic umbrella review of the evidence

  title={The serotonin theory of depression: a systematic umbrella review of the evidence},
  author={Joanna Moncrieff and Ruth E. Cooper and Tom Stockmann and Simone Amendola and Michael Pascal Hengartner and Mark Abie Horowitz},
  journal={Molecular Psychiatry},
  pages={1 - 14}
The serotonin hypothesis of depression is still influential. We aimed to synthesise and evaluate evidence on whether depression is associated with lowered serotonin concentration or activity in a systematic umbrella review of the principal relevant areas of research. PubMed, EMBASE and PsycINFO were searched using terms appropriate to each area of research, from their inception until December 2020. Systematic reviews, meta-analyses and large data-set analyses in the following areas were… 

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