The serotonin system and spiritual experiences.
@article{Borg2003TheSS, title={The serotonin system and spiritual experiences.}, author={Jacqueline Borg and Bengt Andr{\'e}e and Henrik Soderstrom and Lars Farde}, journal={The American journal of psychiatry}, year={2003}, volume={160 11}, pages={ 1965-9 } }
OBJECTIVE
The serotonin system has long been of interest in biological models of human personality. The purpose of this positron emission tomography (PET) study was to search for relationships between serotonin 5-HT(1A) receptor density and personality traits.
METHOD
Fifteen normal male subjects, ages 20-45 years, were examined with PET and the radioligand [(11)C]WAY100635. Personality traits were assessed with the Swedish version of the Temperament and Character Inventory self-report…
206 Citations
Relationship Between Neuroticism Personality Trait and Serotonin Transporter Binding
- PsychologyBiological Psychiatry
- 2007
No association between serotonin 5-HT1A receptors and spirituality among patients with major depressive disorders or healthy volunteers
- Psychology, BiologyMolecular Psychiatry
- 2011
The results do not support the idea that the serotonin system forms the biological basis of spiritual experiences among patients suffering from major depressive disorder or among healthy volunteers.
No evidence for a role of the serotonin 4 receptor in five-factor personality traits: A positron emission tomography brain study
- Biology, PsychologyPloS one
- 2017
The findings indicate that NEO personality traits and 5-HT4R are not related in healthy participants and suggest that5-HT tone per se is not directly implicated in normal personality traits.
Serotonin 5-HT1A receptor binding and self-transcendence in healthy control subjects—a replication study using Bayesian hypothesis testing
- Biology, PsychologyPeerJ
- 2018
A replication of the original study in a larger sample using Bayesian hypothesis testing could not replicate the previous findings of an association between 5-HT1A availability and the personality trait ST/SA, and the Bayesian analysis provided evidence for a lack of correlation.
Serotonin 5-HT1A receptor binding and self-transcendence in healthy control subjects - a replication study using Bayesian hypothesis testing
- Psychology, BiologybioRxiv
- 2017
A replication of the original study in a larger sample using Bayesian hypothesis testing could not replicate the previous findings of an association between 5-HT1A availability and the personality trait ST/SA, and the Bayesian analysis provided evidence for a lack of correlation.
Temperament, character and serotonin activity in the human brain: a positron emission tomography study based on a general population cohort
- PsychologyPsychological Medicine
- 2012
A link between high serotonin transporter density and high ‘self-directedness’ (ability to adapt and control one's behaviour to fit situations in accord with chosen goals and values) is found.
Self-transcendence trait and its relationship with in vivo serotonin transporter availability in brainstem raphe nuclei: An ultra-high resolution PET-MRI study
- BiologyBrain Research
- 2015
Genes encoding for AP-2β and the Serotonin Transporter are associated with the Personality Character Spiritual Acceptance
- BiologyNeuroscience Letters
- 2007
The personality trait openness is related to cerebral 5-HTT levels
- Psychology, BiologyNeuroImage
- 2009
Search for correlations between serotonin 5-HT1A receptor expression and cognitive functions—a strategy in translational psychopharmacology
- Psychology, BiologyPsychopharmacology
- 2006
The results do not provide support for involvement of the 5-HT1A receptor in cognitive functioning in man and question the predictive validity of some currently used animal models in translational neuroscience.
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