The serotonin syndrome.

  title={The serotonin syndrome.},
  author={Harvey A. Sternbach},
  journal={The American journal of psychiatry},
  volume={148 6},
  • H. Sternbach
  • Published 1991
  • Psychology, Medicine
  • The American journal of psychiatry
OBJECTIVE AND METHOD A review of the literature on the serotonin syndrome in animals and human beings was conducted, and 12 reports of 38 cases in human patients were then analyzed to determine the most frequently reported clinical features and drug interactions, as well as the incidence, treatment, and outcome of this syndrome. FINDINGS The serotonin syndrome is most commonly the result of the interaction between serotonergic agents and monoamine oxidase inhibitors. The most frequent… Expand
A case of serotonin syndrome and mutism associated with methadone.
Serotonin syndrome is becoming more common, and with the utilization of polypharmacy on many palliative care services should be considered as unifying differential diagnosis in the appropriate setting. Expand
Treatment of the serotonin syndrome with cyproheptadine.
The role of specific serotonin receptor antagonists such as cyproheptadine in the treatment of the serotonin syndrome remains to be delineated and its use should be considered an adjunct to supportive care. Expand
Serotonin Syndrome—What Have We Learned?
The serotonin syndrome is a complication of serotonergic medications that is being recognized with increasing frequency in both adults and children. Patients present with a constellation of mentalExpand
Serotonin syndrome and drug combinations: focus on MAOI and RIMA
A spectrum of serotonergic hyperactivity, through to a defined serotonin syndrome, may arise from the use or combination of any serotomimetic substance, as this is a consequence of the mechanism involved, rather than the use of any specific product such as the new antidepressants. Expand
Serotonin Syndrome Presentation of 2 Cases and Review of the Literature
It was found that patients with serotonin syndrome most often presented within 24 hours of medication initiation, overdose, or change in dosage, and most patients had complete resolution of their symptoms within 24Hours of presentation. Expand
The Serotonin Syndrome
Because fatalities and severe complications have accompanied the serotonin syndrome, the previously described drug combinations should be used cautiously or not at all. Expand
Serotonin Syndrome and the Anaesthetist
Serotonin syndrome is caused by the administration of one or more drugs possessing serotonergic activity and is likely to be the cause of rhabdomyolysis seen in severe cases and should be treated with benzodiazepines and muscle relaxants. Expand
Pathophysiology and Management of the Serotonin Syndrome
The SS is increasingly recognized and reported in the literature and clinical and basic science research have increased understanding of the pathophysiology, conditions, and agents that may predispose to the development of the syndrome. Expand
The serotonin syndrome: Definition and eause
The serotonin syndrome (SS) is a toxic reaction to a (relative?) hyperserotonergic condition in the brainstern and tne spinal cord. The syndrome is characterized by motoric restlessness and anxiety,Expand
Antidepressants and the serotonin syndrome in general practice.
  • F. J. Mackay, N. Dunn, R. Mann
  • Medicine
  • The British journal of general practice : the journal of the Royal College of General Practitioners
  • 1999
Improved awareness of the serotonin syndrome is needed within general practice, and there is a need to distinguish the relatively minor serotonergic symptoms from those of a severe, life-threatening serotonin syndrome. Expand