The serotonin reuptake inhibitor citalopram does not affect colonic sensitivity or compliance in rats.

@article{Kll2007TheSR,
  title={The serotonin reuptake inhibitor citalopram does not affect colonic sensitivity or compliance in rats.},
  author={Erika K{\"a}ll and Erik Lindstr{\"o}m and Victoria Sanchez Martinez},
  journal={European journal of pharmacology},
  year={2007},
  volume={570 1-3},
  pages={
          203-11
        }
}
Altered serotonin signaling has been implicated in the pathophysiology of irritable bowel syndrome (IBS). Selective serotonin reuptake inhibitors (SSRI) improve IBS symptoms, although the mechanism of action remains unclear. We assessed the effects of the SSRI, citalopram, on colonic sensitivity and compliance in rats after acute and repeated administration. Colorectal distension was performed in conscious rats. Pressure-volume relationships during colorectal distension (2-20 mmHg), fitted… CONTINUE READING
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